Printed and flexible electronics enable interesting novel applications in the fields of sensors and bioelectronics. To design complex circuitry and hybrid integrated systems, the sensor and the near sensor computing part is fabricated in printed electronics, which are complemented by silicon electronics to form an integrated hybrid system. I will show how we have developed a dedicated flexible hybrid organic process design kit, suitable for running in commercial CAD Tools (Cadence Virtuoso) which supports a full front to back design flow. The design flow includes schematic entry, initial simulation, and layout generation for prototyping. Additional we have developed dedicated transistor models, capacitance models as well as parasitic extraction to allow for high precision modelling. As an example for the capability of our FH_OPDK I will show a flexible pressure sensor integrated with an organic active matrix backplane addressed by binary decoders and analog multiplexer based on organic field effect transistors and metal resistors.   [1] G. C. Marques, F. Rasheed, J. Aghassi-Hagmann, M.B. Tahoori, Proceedings of the 23rd Asia and South Pacific Design Automation Conference (ASP-DAC), 658–663, (2018), doi: 10.1109/ASPDAC.2018.8297397 [2] X. Feng, G. Marques; F. Rasheed, M. B. Tahoori, J. Aghassi-Hagmann, IEEE transactions on electron devices, 66 (12), 5272–5277, (2019), doi:10.1109/TED.2019.2947787 [3] This process design kit integrated in the Cadence EDA platform has been developed within the 2-HORISONS project including the cluster members Innovation Lab, Karlsruhe Institute of Technology, University of Heidelberg, BASF, Cadence.